The ferry leaves every half hour (if running) so you should control at either Knott End or Fleetwood as time permits; there is a cafe at both ferry terminals. But don't worry if you miss the ferry, there is an alternative route to Lytham St Annes via Poulton-le-Fylde.
From Fleetwood, follow the Fylde coast through Cleveleys and Blackpool.
After the last control at St Annes, the Perm then has to negotiate Preston but there is a great route through the disused docks using the Guild Wheel Cyclepath as shown on the Preston Cycling Map
The route then takes to the West Pennine Moors with a climb from Darwin onto the Roman Road through Edgeworth before dropping to Bury.
There's a neat bit of cyclepath to get to Pilsworth and avoiding the M66 roundabout at junction 2, which you can see on the TfGM cycling map
The run-in to Uppermill takes you through Middleton, Royton and High Moor.
Getting your Wyres crossed
☕ Some Useful Café Suggestions:
76km: Knott End, Cafe at Ferry terminal 77km: Fleetwood, Cafe at Ferry terminal 100km: Blackpool, Many pubs and cafes 201km: Uppermill, Many cafes, including Abaco and Cellar Pot